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Introduction To Proteins And Amino Acids (article) | Khan Academy
Different types of proteins. The structure and properties of amino acids. Formation of peptide bonds. But if you ever work in a molecular biology lab (say, for a summer internship), protein may start to look very different to you. [ReadMore..]
Mechanical Biochemistry Of Proteins One Molecule At A Time ...
Mar 14, 2008 ... Single-molecule mechanical techniques are providing fundamental information on the structure and function of proteins and are becoming an ... [ReadMore..]
Transport Molecule Forms A Protective Structure To Guide Proteins To ...
Mar 4, 2015 ... The molecular complex that guides an important class of proteins to correct locations in cell membranes does so by forming a dimeric ... [ReadMore..]
Integral Molecular: Antibody Discovery For Membrane Proteins
Integral Molecular provides innovative solutions for antibody discovery against challenging membrane protein targets. Learn more. Integral Molecular provides innovative solutions for antibody discovery against challenging membrane protein targets. Learn more. [ReadMore..]
Mass Spectrometry (Protein & Small Molecule) (CCR) - Center For ...
Mass Spectrometry (Protein & Small Molecule) (CCR) - Center for Cancer ... The laboratory specializes in the identification of individual proteins to the ... [ReadMore..]
A Comprehensive Survey Of Small-Molecule Binding Pockets In ...
Author Summary The life of a living cell relies on many distinct proteins to carry out their functions. Most of these functions are rooted in interactions between the proteins and metabolites, small-molecules essential for life. By targeting specific proteins relevant to a disease, drug molecules may provide a cure. A deep understanding of the nature of interactions between proteins and small-molecules (or ligands) through analyzing their structures may help predict protein function or improve drug design. In this contribution, we present a large-scale analysis of a non-redundant set of over 20,000 experimental protein-ligand complex structures available in the current Protein Data Bank. We seek answers to several fundamental questions: How many representative pockets are there that serve as ligand-binding sites in proteins? To what extent can we infer a similar protein-ligand interaction by matching the structures of protein pockets? How different are the ligands found in the same pocket? For a promiscuous p Oct 24, 2013 ... Author Summary The life of a living cell relies on many distinct proteins to carry out their functions. Most of these functions are rooted ... [ReadMore..]
Intracellular Delivery Of Adamantane-Tagged Small Molecule ...
Herein, we demonstrate a convenient technique for the intracellular delivery of proteins and liposomes based on supramolecular host–guest chemistry. First, we prepared the R8-CDOH carrier molecule, which is a β-cyclodextrin derivative bearing an octaarginine (R8) chain, as a cell-penetrating peptide, at the primary hydroxyl group. The surface amino groups of proteins (GFP, β-gal, and IgG) were then partly modified with adamantane (Ad) tags using 1-Ad-carboxylic acid N-hydroxysuccinimide ester (Ad-NHS). These Ad-tagged proteins were effectively delivered into HeLa cells though supramolecular host–guest interactions with R8-CDOH. A 100 nm sized liposome bearing Ad-tags on its surface was also delivered into these cells by the action of R8-CDOH. The present method does not require any genetic manipulation, and only easy chemical modification processes are used to facilitate intracellular delivery; therefore, we believe that the present method is applicable to a variety of bioengineering processes, such as May 14, 2020 ... Herein, we demonstrate a convenient technique for the intracellular delivery of proteins and liposomes based on supramolecular host–guest ... [ReadMore..]
Protein | Definition, Structure, & Classification | Britannica
protein, highly complex substance that is present in all living organisms. Proteins are of great nutritional value and are directly involved in the chemical processes essential for life. The importance of proteins was recognized by chemists in the early 19th century, including Swedish chemist Jöns Jacob Berzelius, who in 1838 coined the term protein, a word derived from the Greek prōteios, meaning “holding first place.” Proteins are species-specific; that is, the proteins of one species differ from those of another species. They are also organ-specific; for instance, within a single organism, muscle proteins differ from those of the brain and Proteins are of great nutritional value and are directly involved in the ... A protein molecule is very large compared with molecules of sugar or salt and ... [ReadMore..]
The Shape And Structure Of Proteins - Molecular Biology Of The Cell ...
A protein molecule is made from a long chain of these amino acids, each linked to its neighbor through a covalent peptide bond (Figure 3-1). Proteins are ... [ReadMore..]
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Molecule Of The Month: Ebola Virus Proteins - PDB-101
Structures of ebola virus proteins are giving new hope for fighting this deadly virus Once inside cells, the large "L" protein, which is an RNA-dependent RNA polymerase, creates many new copies of the RNA genome. As with the other ebola proteins, ... [ReadMore..]
Single Molecule Biophysics Of Intrinsically Disordered Proteins In ...
Aug 23, 2021 ... August 23rd, 2021 – Jhullian Jamille Alston, BA, Pre-Doc Trainee in the department of Biochemistry and Molecular Biophysics, ... [ReadMore..]