Mitochondria Structure And Function


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Mitochondria: isolation, structure and function - PMC

Mitochondria: Isolation, Structure And Function - PMC

Mitochondria are complex organelles constantly undergoing processes of fusion and fission, processes that not only modulate their morphology, but also their function. Yet the assessment of mitochondrial function in skeletal muscle often involves mechanical ... Jun 27, 2011 ... Yet the assessment of mitochondrial function in skeletal muscle often involves mechanical isolation of the mitochondria, a process which ... [ReadMore..]

Mitochondrial structure and function are disrupted by standard ...

Mitochondrial Structure And Function Are Disrupted By Standard ...

Mitochondria regulate critical components of cellular function via ATP production, reactive oxygen species production, Ca(2+) handling and apoptotic signaling. Two classical methods exist to study mitochondrial function of skeletal muscles: isolated mitochondria and permeabilized myofibers. Whereas … Mar 28, 2011 ... Mitochondria regulate critical components of cellular function via ATP production, reactive oxygen species production, Ca(2+) handling and ... [ReadMore..]

Dynamic post-transcriptional regulation by Mrn1 links cell wall ...

Dynamic Post-transcriptional Regulation By Mrn1 Links Cell Wall ...

Author summary Regulated degradation of messenger RNAs acts together with regulated transcription to determine mRNA abundance and thereby control gene expression. RNA-binding proteins coordinate post-transcriptional gene expression programs by recognizing groups of functionally related transcripts and modulating their stability and decay. Here, we establish that the yeast RNA-binding protein Mrn1 controls a gene expression program that links the mitochondrion with the yeast cell wall. The cell wall is a dynamic structure that withstands substantial osmotic pressure while undergoing continuous remodeling during growth and division. It comprises a large fraction of the cell’s dry weight and consumes substantial energy as well as carbohydrates. Mrn1 binds hundreds of target mRNAs, which are enriched for functions in cell wall organization and biogenesis. We found that Mrn1 destabilizes these targets during glucose fermentation, but its repressive effect is relieved when cells switch to respiratory growth. Cell Apr 15, 2021 ... Mrn1 control of Nca3 and other genes sculpts mitochondria and the cell ... cell wall homeostasis to mitochondrial structure and function. [ReadMore..]

Drosophila MICOS knockdown impairs mitochondrial structure and ...

Drosophila MICOS Knockdown Impairs Mitochondrial Structure And ...

The mitochondrial contact site and cristae organizing system (MICOS) is a multi-protein interaction hub that helps define mitochondrial ultrastructure. While the functional importance of MICOS is mostly characterized in yeast and mammalian cells in culture, the contributions of MICOS to tissue homeo … Dec 2, 2020 ... In this study, we examined how knocking down expression of Drosophila MICOS genes affects mitochondrial function and muscle tissue homeostasis. [ReadMore..]

Bid maintains mitochondrial cristae structure and function and ...

Bid Maintains Mitochondrial Cristae Structure And Function And ...

An integrative approach, combining genetic mouse and large-scale human genetics studies, was used to reveal a novel role for the Bcl-2 protein Bid in maintenance of mitochondrial function that alters susceptibility to myocardial infarction. Oct 3, 2018 ... Bid's role in regulating cristae structure has been limited to in vitro studies focusing on isolated mitochondria and cBid. cBid's interaction ... [ReadMore..]

mitochondrion | Definition, Function, Structure, & Facts | Britannica

Mitochondrion | Definition, Function, Structure, & Facts | Britannica

mitochondrion, membrane-bound organelle found in the cytoplasm of almost all eukaryotic cells (cells with clearly defined nuclei), the primary function of which is to generate large quantities of energy in the form of adenosine triphosphate (ATP). Mitochondria are typically round to oval in shape and range in size from 0.5 to 10 μm. In addition to producing energy, mitochondria store calcium for cell signaling activities, generate heat, and mediate cell growth and death. The number of mitochondria per cell varies widely—for example, in humans, erythrocytes (red blood cells) do not contain any mitochondria, whereas liver cells and muscle cells may mitochondrion, membrane-bound organelle found in the cytoplasm of almost all eukaryotic cells (cells with clearly defined nuclei), the primary function of ... [ReadMore..]

Structure and function of mitochondrial membrane protein ...

Structure And Function Of Mitochondrial Membrane Protein ...

Oct 29, 2015 ... Mitochondria are the powerhouses of the cell. In all eukaryotes that do not depend on photosynthesis, the mitochondria are the main source of ... [ReadMore..]

Regulation of mitochondrial structure and function by the F1Fo ...

Regulation Of Mitochondrial Structure And Function By The F1Fo ...

When mitochondrial respiration is compromised, the F(1)F(o)-ATP synthase reverses and consumes ATP, serving to maintain the mitochondrial membrane potential (Delta psi(m)). This process is mitigated by IF(1). As little is known of the cell biology of IF(1), we have investigated the functional conseq … Regulation of mitochondrial structure and function by the F1Fo-ATPase inhibitor protein, IF1. Cell Metab. 2008 Jul;8(1):13-25. doi: ... [ReadMore..]

Synthetic Control of Mitochondrial Dynamics: Developing Three ...

Synthetic Control Of Mitochondrial Dynamics: Developing Three ...

Mitochondrial structure and organization is integral to maintaining mitochondrial homeostasis and an emerging biological target in aging, inflammation, neurodegeneration, and cancer. The study of mitochondrial structure and its functional implications remains challenging in part because of the lack of available tools for direct engagement, particularly in a disease setting. Here, we report a gold-based approach to perturb mitochondrial structure in cancer cells. Specifically, the design and synthesis of a series of tricoordinate Au(I) complexes with systematic modifications to group 15 nonmetallic ligands establish structure–activity relationships (SAR) to identify physiologically relevant tools for mitochondrial perturbation. The optimized compound, AuTri-9 selectively disrupts breast cancer mitochondrial structure rapidly as observed by transmission electron microscopy with attendant effects on fusion and fission proteins. This phenomenon triggers severe depolarization of the mitochondrial membrane in can Mar 9, 2021 ... The study of mitochondrial structure and its functional implications remains challenging in part because of the lack of available tools for ... [ReadMore..]

The Functional Impact of Mitochondrial Structure Across ... - Frontiers

The Functional Impact Of Mitochondrial Structure Across ... - Frontiers

Nov 11, 2020 ... Mitochondria are key determinants of cellular health. However, the functional role of mitochondria varies from cell to cell depending on the ... [ReadMore..]

Cardiac nuclear receptors: architects of mitochondrial structure and ...

Cardiac Nuclear Receptors: Architects Of Mitochondrial Structure And ...

The adult heart is uniquely designed and equipped to provide a continuous supply of energy in the form of ATP to support persistent contractile function. This high-capacity energy transduction system is the result of a remarkable surge in mitochondrial ... Feb 13, 2017 ... In this Review, we describe the role of specific nuclear receptors and their coregulators in the dynamic control of mitochondrial biogenesis and ... [ReadMore..]