How Do Olfactory Receptors Work


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Olfactory Receptor - an overview | ScienceDirect Topics

Olfactory Receptor - An Overview | ScienceDirect Topics

Olfactory receptors (ORs) belong to the G-protein-coupled receptor family and play a critical role in recognizing thousands of odorant molecules in the ... [ReadMore..]

Human Olfactory Receptors: Novel Cellular Functions Outside of the ...

Human Olfactory Receptors: Novel Cellular Functions Outside Of The ...

Olfactory receptors (ORs) are not exclusively expressed in the olfactory sensory neurons; they are also observed outside of the olfactory system in all other human tissues tested to date, including the testis, lung, intestine, skin, heart, and blood. Within these tissues, certain ORs have been determined to be exclusively expressed in only one tissue, whereas other ORs are more widely distributed in many different tissues throughout the human body. For most of the ectopically expressed ORs, limited data are available for their functional roles. They have been shown to be involved in the modulation of cell-cell recognition, migration, proliferation, the apoptotic cycle, exocytosis, and pathfinding processes. Additionally, there is a growing body of evidence that they have the potential to serve as diagnostic and therapeutic tools, as ORs are highly expressed in different cancer tissues. Interestingly, in addition to the canonical signaling pathways activated by ORs in olfactory sensory neurons, alternative pat Jun 13, 2018 ... Olfactory receptors (ORs) detect volatile chemicals that are common odorants in the environment. In 1991, Linda Buck and Richard Axel (21) ... [ReadMore..]

How COVID-19 Causes Loss of Smell | Harvard Medical School

How COVID-19 Causes Loss Of Smell | Harvard Medical School

Olfactory support cells, not neurons, are vulnerable to novel coronavirus infection Jul 24, 2020 ... ... the research team found that olfactory sensory neurons do not express the gene that encodes the ACE2 receptor protein, which SARS-CoV-2 ... [ReadMore..]

Dogs' Dazzling Sense of Smell | NOVA | PBS

Dogs' Dazzling Sense Of Smell | NOVA | PBS

What lies behind their exceptional gift of sniff? Oct 3, 2012 ... What do dogs have that we don't? For one thing, they possess up to 300 million olfactory receptors in their noses, compared to about six ... [ReadMore..]

Olfactory Receptors in Non-Chemosensory Organs: The ... - Frontiers

Olfactory Receptors In Non-Chemosensory Organs: The ... - Frontiers

Jul 5, 2016 ... Odorant and pheromone receptors are specialized chemical receptors designed to recognize and respond to volatile molecules by activating down- ... [ReadMore..]

Olfactory receptor function

Olfactory Receptor Function

Olfaction plays a critical role in several aspects of life. Olfactory disorders are very common in the general population, and can lead to malnutrition, weight loss, food poisoning, depression, and other disturbances. Odorants are first detected in the upper region of the nose by the main olfactory … The binding of odors to the ORs initiates an electrical signal that travels along the axons to the main olfactory bulb of the brain. The information is then ... [ReadMore..]

A genetic variant near olfactory receptor genes influences cilantro ...

A Genetic Variant Near Olfactory Receptor Genes Influences Cilantro ...

Nov 29, 2012 ... Among these olfactory receptor genes is OR6A2, which has a high binding ... It has no known function in taste or smell and did not show ... [ReadMore..]

Olfactory receptor - Wikipedia

Olfactory Receptor - Wikipedia

Activated olfactory receptors trigger nerve impulses which transmit information about odor to the brain. These receptors are members of the class A rhodopsin- ... [ReadMore..]

Olfactory receptor accessory proteins play crucial roles in receptor ...

Olfactory Receptor Accessory Proteins Play Crucial Roles In Receptor ...

G protein-coupled odorant receptors regulate their own gene transcription based on their cell surface trafficking, which is facilitated by receptor transporting protein (RTP) family members. Mar 6, 2017 ... They do so by using hundreds of unique sensors called olfactory receptors, each of which responds to a specific type of odor. [ReadMore..]

Mechanism Revealed Behind Loss of Smell with COVID-19 | NYU ...

Mechanism Revealed Behind Loss Of Smell With COVID-19 | NYU ...

NYU Langone researchers say their work describes a mechanism that may partly explain hyposmia and other neurological effects of long COVID-19. Learn more. Feb 2, 2022 ... NYU Langone researchers say their work describes a mechanism that may ... memory” that could prevent the restoration of olfactory receptor ... [ReadMore..]

Olfactory receptors - Latest research and news | Nature

Olfactory Receptors - Latest Research And News | Nature

Olfactory receptors are able to detect air-borne odour molecules that enter the nasal cavity and bind to olfactory receptors. The activation of olfactory ... [ReadMore..]